FC Effector Activity Bioassays

Our ADCC and ADCP Reporter Bioassays are biologically relevant, MOA-based assays that can be used to measure the potency and stability of antibodies and other biologics that specifically bind and activate Fcγ receptors. The assays consist of Jurkat cells stably expressing the relevant Fcγ receptor variant and a luciferase gene regulated by the NFAT response element.

Fc receptors are proteins expressed on the surface of immune cells that contribute to the protective functions of the immune system. By binding antibodies attached to the surface of target cells, Fc receptors initiate cytotoxic or phagocytic effector cell activity.