Recording Webinar Targeted Protein Degradation of HaloTag® Fusion Protein for Phenotypic Studies

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that recruit target proteins for degradation via the ubiquitin proteasomal pathway. Traditional small-molecule drugs have focused on inhibition of the target protein; however, many targets do not have accessible binding sites. PROTACs offer an exciting opportunity to “drug the undruggable” by tagging the target for degradation. This webinar introduces a new small-molecule degrader that specifically binds to and degrades the HaloTag® protein and its fusion partners in live cells. Following targeted degradation, phenotypic studies can be accomplished to understand the physiological impact of the small molecule drug on the cell.

In this webinar, you will learn :

• The mechanism of HaloPROTAC3 targeted protein degradation
• Options for the expression of HaloTag® fusions for HaloPROTAC3 degradation
• Methods to detect the degradation of HaloTag® fusions after HaloPROTAC3 treatment

Registration link : https://bit.ly/3xIGFrJ