WEBINAR Development of a Microsatellite Instability Assay Utilizing Novel Long Repeats 10 November 2022

FREE PROMEGA WEBINAR

Date : 10th October 2022
Time : 11 am (Indonesia)

Promega Webinar, In this webinar we will discuss Characterizing MS status in challenging samples, including those with ambiguous results or small shifts, can be difficult. Endometrial and other cancers tend to have fewer, smaller marker shifts making MSI analysis cumbersome. Research suggests that mismatch repair deficiency causes proportionally more disruption to longer markers with repeat regions, particularly long mononucleotide repeats. This means shifts in longer markers tend to be greater thus more readily detected by fragment analysis. In this webinar, Dr. Samantha Lewis describes the development of a new PCR assay to detect MSI in solid tumors utilizing a new 8-marker panel that includes both gold standard markers and novel long mononuceotide repeats for a research-based approach to maximize sensitivity. She will also demonstrate the utility of this novel panel by showcasing studies using difficult and degrated samples (cefDNA and FFPE).

In this webinar, you will learn:
• How mismatch repair deficiency causes MSI and techniques to measure MSI
• How long mononucleotide markers may offer a different perspective on MSI in difficult sample types
• Why a panel used to detect MSI should include an optimal number of highly sensitive, well-characterized markers.

Free Link Webinar : https://bit.ly/3zOEciq