Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that recruit target proteins for degradation via the ubiquitin proteasomal pathway. Traditional small-molecule drugs have focused on inhibition of the target protein; however, many targets do not have accessible binding sites. PROTACs offer an exciting opportunity to “drug the undruggable” by tagging the target for degradation. This webinar introduces […]
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