Description
Fc receptor-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action (MOA) by which antibodies target disease cells for elimination.
The ADCC Reporter Bioassays, F Variant, use NFAT-mediated luciferase activity in effector cells as indicator of ADCC MOA, providing an alternative to traditional primary cell-based assays for measuring the effect of biologics on ADCC activity.
They are accurate, precise and stability-indicating and prequalified according to ICH guidelines, making them suitable for all stages of biologic research and development.
Features – Benefits
- No cell culture required
- Quantitate impact of F158 polymorphism on Fc effector function
- Supplied in convenient thaw-and-use format; also available in cell propagation model (CPM) format
| Product | Size | Catalog |
| ADCC Reporter Bioassay, F Variant, Core Kit | 1X Each Component | G9790 |
| 5X Each Component | G9798 | |
| ADCC Reporter Bioassay, F Variant, Cell Propagation model | 2 × 1 ml | G9302 |
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