T Cell Activation Bioassays

Novel biologics formats, including bispecific antibodies and CAR-T cell therapies, require robust, reproducible measurement of T cell activation. Our ICH-prequalified bioassays enable simple, scalable solutions for drug screening and development.

These assays consist of a genetically engineered T cell line that expresses a luciferase reporter driven by either an NFAT response element or an IL-2 promoter. When engaged with either an anti-TCR/CD3 stimulus alone or an anti-TCR/CD3 and an anti-CD28 stimulus, receptor-mediated signaling induces luminescence.