Genetic Reporter Vectors and Cell Lines

The conventional use of reporter genes is to analyze gene expression and dissect the function of cis-acting genetic elements such as promoters and enhancers. However, the broader aspect of gene expression entails much more than transcription alone, and reporter genes also can be used to study other cellular events, such as miRNA regulation. The features of a reporter vector will depend on the intended application and generally include a form of the reporter gene, upstream elements such as a promoter or response element, and often a selectable marker to allow for stable cell line generation.

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