. 23/06/2021 Understanding how a small molecule compound interacts with its target protein is essential for developing successful drugs. In vitro measurements of ligand affinity and duration of drug-target interactions (e.g., residence time) often do not translate in vivo. Using the NanoBRET™ Target Engagement (TE) method, we will show the impact of oncogenic KRAS (G12C) […]
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17/06/2021 Vaccine development efforts primarily focus on the generation of neutralizing antibodies that block viral entry, as illustrated by the success of SARS-CoV-2 vaccines. However, this strategy has yielded disappointing results for herpes simplex virus (HSV). This webinar will discuss the role of antibody-dependent cell mediated cytotoxicity (ADCC) and antibody dependent cell-mediated phagocytosis (ADCP) in […]
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