06/05/2021 The Dynamics of Compound Profiling: Using Signaling Kinetic Assays to Shape Early-Stage Drug DiscoveryIn vitro early-stage compound profiling often focuses on single timepoint measurements of drug action. However, in vivo, drug action occurs not at equilibrium, but within a highly dynamic system. This webinar will explore how measuring the kinetics of drug-target interaction and […]
> Read moreCategory: Recording Webinar
Want to get more physiologically relevant data from 3D cultures? In this webinar, we will demonstrate how to use hydrogels for organoid and cancer studies to better simulate tissue microenvironment. We will also discuss how to validate cell-based assays in 3D microtissues to ensure accurate results. In this webinar, you will learn about: Saving time […]
> Read more
In preparation for eventual “test-all” legislation for procession sexual assault kits, the Forensic Biology Unit at the Palm Beach County Sheriff’s Office (FBU) began the quest for a solution to increase casework handling capacity, without increasing staff. With a validating Y-screening, direct-to-DNA workflow, the FBU could triage samples to improve processing efficiency. This webinar details […]
> Read more
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that recruit target proteins for degradation via the ubiquitin proteasomal pathway. Traditional small-molecule drugs have focused on inhibition of the target protein; however, many targets do not have accessible binding sites. PROTACs offer an exciting opportunity to “drug the undruggable” by tagging the target for degradation. This webinar introduces […]
> Read more
